In his research he focuses on mechanisms of ictogenesis and functional organization of epileptic foci. Currently, he works at Institute of Physiology, Academy of Sciences of Czech Republic.
Premysl Jiruska is former Epilepsy Research UK fellow. These recent advances have challenged long-established views and are leading to a more rigorous and realistic understanding of the pathophysiology of epilepsy. Recent work has identified cell-type-specific inhibitory and excitatory interactions, the dichotomy between neuronal firing and the non-local measurement of local field potentials distant to that firing, and the reflection of the neuronal dark matter problem in non-firing neurons active in seizures.
In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Desynchronization is often observed preceding seizures or during their early stages in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination.
Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state.
0 kommentar(er)
